A Fat Man Alien Blaster? It's possible with this mod.
A new mod for Fallout 4 removes the restriction on the number of mods you can apply to any weapon in the game, as reported by Kotaku.
LucasGod’s ‘Any Mod Any Weapon‘ mod for PC, allows you to make and combine weapons which would normally be impossible in the game. “[The mod is] not balanced, not immersive, and might even affect the non-unique weapons carried by enemies you find in the wild or on stores,” LucasGod cautions. “But it’s really fun!”
The Borderlands-like abilities granted by the mod allow you to combine the likes of the Alien Blaster and the Fat Man if you so wish, or create a target seeking quad-barrel minigun.
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The video below by Tyrannicon shows the mod in action: